Colorado vs. Nebraska prediction, odds: 2024 college football expert picks, Deion Sanders bets

Longtime rivals are set to square off when Matt Rhule and the Nebraska Cornhuskers (1-0) host Deion Sanders and the Colorado Buffaloes (1-0) on Saturday at Memorial Stadium in Lincoln. The Huskers used a solid performance from highly-touted freshman quarterback Dylan Raiola to notch a 40-7 Week 1 win over UTEP. The Buffs kicked off year two under Coach Prime with a hard-fought 31-26 win over North Dakota State. Quarterback Shedeur Sanders and two-way star Travis Hunter looked like legitimate Heisman Trophy contenders in the win. Nebraska leads the all-time series 49-21-2, but Colorado has won three-straight in the rivalry, including a 36-14 win in 2023.

Kickoff is at 7:30 p.m. ET from Memorial Stadium in Lincoln, Nebraska. The Huskers are 6.5-point favorites in the latest Colorado vs. Nebraska odds, per SportsLine consensus. The over/under for total points is 55.5. Before making any Nebraska vs. Colorado picks, you need to see the Week 2 college football predictions and betting advice from SportsLine’s Jimmie Kaylor. 

Kaylor is an NFL, college football and DFS expert for SportsLine, who has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America. His background as a former college football All-American and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks. He has his finger on the pulse of the college football landscape and has been cashing in big for the last two years. 

Kaylor destroyed the books in college football in 2023, netting a whopping 57.9 units while posting a 107-45-2 record. Anyone who followed his picks finished the season way up.

Now, Kaylor has dialed in on Colorado vs. Nebraska on Saturday and just revealed his picks and predictions. You can head to SportsLine now to see his picks. Here are the college football odds and college football betting lines on the spread, money line, and over/under for Nebraska vs. Colorado:

• Colorado vs. Nebraska spread: Nebraska -6.5
• Colorado vs. Nebraska over/under: 55.5 points
• Colorado vs. Nebraska money line: Nebraska -243, Colorado +196
• Colorado vs. Nebraska picks: See picks at SportsLine

Why Colorado can cover

Dylan Raiola may prove to be the savior of Nebraska football, but Colorado has an undeniable edge at the quarterback position in senior Shedeur Sanders. The 6-foot-2, 215-pound Sanders threw for 445 yards and four touchdowns in CU’s season opening win. Sanders led Colorado to a 36-14 win over Nebraska in 2023.

Colorado also has a group of wide receivers that will be a tough test for Nebraska’s secondary. Two-way star Travis Hunter put forth a Heisman Trophy-caliber performance against North Dakota State, catching seven passes for 132 yards and three touchdowns, while also recording three tackles on defense. Jimmy Horn Jr., Will Sheppard and LaJohntay Wester round out the Buffs’ receiving corps. Horn caught seven passes for 198 yards and a touchdown against NDSU. See which team to pick here.

Why Nebraska can cover

The Huskers project to have a significant advantage up front on both sides of the ball. Colorado revamped both its offensive and defensive lines during the offseason, but both units struggled mightily against North Dakota State. The Buffs rushed for only 59 yards against NDSU, forcing them to be one-dimensional on offense. There will be opportunities for the Huskers to exploit this mismatch on Saturday night.

Raiola is the most talented quarterback Nebraska has had in well over a decade. The former five-star recruit was sharp in his debut, completing 70.4% of his passes for 238 yards and two touchdowns. NDSU quarterback Cam Miller picked apart the Colorado defense in Week 1, and Raiola is fully capable of doing the same in Week 2. See which team to pick here.

How to make Nebraska vs. Colorado picks

Kaylor has analyzed Colorado vs. Nebraska from every angle and he’s leaning Over on the point total. He has also discovered a critical X-factor that has him jumping all over one side of the spread. He’s only sharing what it is, and which side to back, at SportsLine.

So who wins Colorado vs. Nebraska on Saturday in Lincoln, and what critical X-factor makes one side of the spread a must back? Visit SportsLine now to see which side of the spread to jump on, all from the expert who profited $5,790 for $100 college football bettors in 2023, and find out.